Clinical Update quiz
The Clinical Update online is a free member service providing up to 11 FREE CPD hours per year.
Each month, the Clinical Update is published online. There are 11 Clinical Updates per year (February - December). This service is available to ADAVB and ADATas members only. Members can log in to view and answer the Clinical Update questions. If you answer at least eight out of 10 questions correctly, you will receive one hour of scientific CPD.
Please note: Each new Clinical Update will be available below from the first business day of each month.
September Clinical Update
Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the volumetric contraction of post-extraction sockets: a double-blinded randomized controlled clinical trial.
Araujo LML, Walterson MP, Zenobio EG, Faverani LP, Souza JGS, Fernandes GVO, Shibli JA. Quint Int 2025; 56(5): 364-374
Compiled by Dr Sarah Chin
Reviewed and edited by Professor Harcourt and Dr Condon.
Permission to use this article was granted by Quintessence Publishing on 26/5/25.
This article was originally published by Quintessence Publishing and has been edited for brevity and clarity.
Aim
After extraction of a tooth, alveolar bone loss is seen in both horizontal and vertical dimensions. The buccal plate may be lost due to the healing process or trauma from the extraction procedure. The most significant time of alveolar bone loss occurs in the first few months with 3-5mm loss in six months. Some studies have reported more than half the ridge is resorbed by six months and is greater at the buccal aspect of the alveolar bone which causes aesthetic issues for crowns and implant supported prostheses.
Studies have aimed to reduce this type of bone loss using bone grafts with xenografts and alloplastic grafts achieving good results for alveolar preservation. Bone morphogenic proteins (BMPs), in particular BMP-2 and BMP-7 have been studied to increase the available bone when used in conjunction with a bone graft. When a larger osteotomy was present, rhBMP-7 significantly increased bone formation, however it had little effect when a normal osteotomy was present for implant placement.
Non-glycosylated (ng)/rhBMP-2 has been used as a coating on titanium implants with and without hydroxyapatite (HA) coating. ng/rhBMP-2 resulted in a greater bone surface area compared with the HA implants and this was more significant than the combined HA and ng/rhBMP-2 coated implants. Implants soaked in 3.0mg/mL rhBMP-2 did not show an increase in bone formation compared with groups receiving 0.75 and 1.5mg/mL at 8 weeks. The objective of this human prospective randomised controlled trial was to evaluate the effect of 1.5mg/mL rhBMP-2 in socket preservation.
Members click here to continue reading and complete this month's Clinical Update questions online or download the current quiz below.
